About 'h4 led'|guided lighting Daytime Running Lights LED

About 'h4 led'|guided lighting Daytime Running Lights LED

Ｉｎｖｅｓｔｉｇａｔｏｒｓ               ａｔ               ｔｈｅ               Ｗａｓｈｉｎｇｔｏｎ               Ｕｎｉｖｅｒｓｉｔｙ               Ｓｃｈｏｏｌ               ｏｆ               Ｍｅｄｉｃｉｎｅ               ｉｎ               Ｓｔ. Ｌｏｕｉｓ               ｈａｖｅ               ｍａｄｅ               ａ               ｋｅｙ               ｄｉｓｃｏｖｅｒｙ               ｔｈａｔ               ｃｏｕｌｄ               ｍａｋｅ               ｒａｄｉａｔｉｏｎ               ｔｈｅｒａｐｙ               ｍｏｒｅ               ｅｆｆｅｃｔｉｖｅ               ｉｎ               ｃａｎｃｅｒ               ｐａｔｉｅｎｔｓ. Ｔｈｉｓ               ｉｓ               ａｃｃｏｒｄｉｎｇ               ｔｏ               ａ               ｎｅｗ               ｒｅｓｅａｒｃｈ               ｐａｐｅｒ               ｐｕｂｌｉｓｈｅｄ               ｉｎ               ｔｈｅ               ｐｒｅｓｔｉｇｉｏｕｓ               ｃｅｌｌ               ｂｉｏｌｏｇｉｃａｌ               ｊｏｕｒｎａｌ               Ｍｏｌｅｃｕｌａｒ               ａｎｄ               Ｃｅｌｌｕｌａｒ               Ｂｉｏｌｏｇｙ. Ｒａｄｉａｔｉｏｎ               ｔｈｅｒａｐｙ               ａｉｍｓ               ａｔ               ｄｅｓｔｒｏｙｉｎｇ               ｔｕｍｏｒｓ               ｂｙ               ｈｉｔｔｉｎｇ               ｔｈｅｍ               ｗｉｔｈ               ｈｉｇｈ-ｅｎｅｒｇｙ               ｒａｄｉａｔｉｏｎ. Ａ               ｋｅｙ               ｉｎ               ｍａｋｉｎｇ               ｒａｄｉａｔｉｏｎ               ｔｒｅａｔｍｅｎｔ               ｅｆｆｅｃｔｉｖｅ               ｉｓ               ｂｅｉｎｇ               ａｂｌｅ               ｔｏ               ａｃｃｅｓｓ               ｔｕｍｏｒｓ               ｅｆｆｅｃｔｉｖｅｌｙ.                Ｒａｄｉａｔｉｏｎ               ｏｎｃｏｌｏｇｉｓｔｓ               ａｒｅ               ａｌｗａｙｓ               ｌｏｏｋｉｎｇ               ｆｏｒ               ｗａｙｓ               ｔｏ               ｉｎｃｒｅａｓｅ               ｔｈｅ               ｅｆｆｅｃｔｉｖｅｎｅｓｓ               ｏｆ               ｒａｄｉａｔｉｏｎ               ｔｈｅｒａｐｙ. Ｏｎｅ               ｗａｙ               ｔｏ               ｄｏ               ｔｈａｔ               ｉｓ               ｔｏ               ｉｎｃｒｅａｓｅ               ｔｈｅ               ｓｅｎｓｉｔｉｖｅｎｅｓｓ               ｏｆ               ｔｕｍｏｒｓ               ｔｏ               ｔｈｅ               ｒａｄｉａｔｉｏｎ                Ｉｔ               ｓｅｅｍｓ               ｔｈａｔ               ｒｅｓｅａｒｃｈｅｓ,               ｌｅｄ               ｂｙ               Ｄｒ. Ｇｕｐｔａ,               ｈａｖｅ               ｆｏｕｎｄ               ａ               ｎｅｗ               ｗａｙ               ｔｏ               ｄｏ               ｔｈａｔ. Ｈｅ               ａｎｄ               ｈｉｓ               ｃｏｌｌｅａｇｕｅｓ               ｒｅｐｏｒｔ               ｔｈｅ               ｄｉｓｃｏｖｅｒｙ               ｏｆ               ａｎ               ｅｎｚｙｍｅ,               ｃａｌｌｅｄ               ＭＯＦ               ｔｈａｔ               ｃｏｕｌｄ               ｈｅｌｐ               ｍａｋｅ               ｔｕｍｏｒｓ               ｍｏｒｅ               ｓｕｓｃｅｐｔｉｂｌｅ               ｔｏ               ｔｈｅ               ｒａｄｉａｔｉｏｎ               ｋｉｌｌｉｎｇ               ｐｏｗｅｒ.                Ｔｈｅ               ｅｎｚｙｍｅ               ＭＯＦ               ｃｏｎｔｒｏｌｓ               ｈｏｗ               ｔｈｅ               ｇｅｎｅｔｉｃ               ｍａｔｅｒｉａｌ               ｏｆ               ｔｈｅ               ｃｅｌｌ               (ＤＮＡ)               ｉｓ               ａｓｓｅｍｂｌｅｄ               ａｎｄ               ｓｔｏｒｅｄ               ｗｉｔｈｉｎ               ａ               ｃｅｌｌ. Ｉｔ               ｉｓ               ａ               ｋｅｙ               ｃｏｍｐｏｎｅｎｔ               ｉｎ               ｃｅｌｌ               ｄｅｖｅｌｏｐｍｅｎｔ               ａｎｄ               ｇｒｏｗｔｈ               ｓｏ               ｉｔ               ｉｓ               ｒｅｌａｔｅｄ               ｔｏ               ｔｈｅ               ｄｅｖｅｌｏｐｍｅｎｔ               ｏｆ               ｔｕｍｏｒｓ               ａｎｄ               ｃａｎｃｅｒ. Ａｃｃｏｒｄｉｎｇ               ｔｏ               ｔｈｅ               ａｕｔｈｏｒｓ               ｏｆ               ｔｈｅ               ｐａｐｅｒ               ｉｓ               ｐｏｓｓｉｂｌｅ               ｔｏ               ｍａｎｉｐｕｌａｔｅ               ｔｈｉｓ               ＭＯＦ               ｅｎｚｙｍｅ               ｔｏ               ｍａｋｅ               ｔｕｍｏｒｓ               ｍｏｒｅ               ｓｅｎｓｉｔｉｖｅ               ｔｏ               ｒａｄｉａｔｉｏｎ.                Ｗｈａｔ               ｄｏｅｓ               ＭＯＦ               ｄｏ? ＭＯＦ               ａｃｔｓ               ｂｙ               ａｄｄｉｎｇ               ａ               ｃｈｅｍｉｃａｌ               ｓｉｇｎａｌ               ｔｏ               ｔｈｅ               ｍａｔｅｒｉａｌ               ｔｈａｔ               ｈｏｌｄ               ｔｈｅ               ｌｏｎｇ               ｃｈａｉｎｓ               ｏｆ               ＤＮＡ               (ＤＮＡ               ｉｓ               ａ               ｄｏｕｂｌｅ               ｈｅｌｉｘ               ｈｏｌｄ               ｔｏｇｅｔｈｅｒ               ｂｙ               ｓｏｍｅ               ｋｉｎｄ               ｏｆ               ｓｐｏｏｌｓ). Ｔｈｅｓｅ               ｓｐｏｏｌｓ               ａｒｅ               ｍａｄｅ               ｏｆｆ               ｐｒｏｔｅｉｎｓ               ｃａｌｌｅｄ               ｈｉｓｔｏｎｅｓ. ＭＯＦ               ａｄｄｓ               ｓｏｍｅｔｈｉｎｇ               ｔｏ               ｔｈｉｓ               ｓｐｏｏｌｓ               ｔｈａｔ               ｍａｋｅｓ               ｔｈｅ               ＤＮＡ               ｓｔｒｕｃｔｕｒｅ               ｍｏｒｅ               ｒｅｌａｘｅｄ.                Ｉｆ               ｔｈｅ               ｃｅｌｌｓ               ｄｏ               ｎｏｔ               ｈａｖｅ               ｔｈｅ               ｅｎｚｙｍｅ               ＭＯＦ               ｔｈｅｙ               ｗｉｌｌ               ｉｎｅｖｉｔａｂｌｙ               ｄｉｅ               ｓｉｎｃｅ               ｔｈｉｓ               ｅｎｚｙｍｅ               ｉｓ               ａ               ｋｅｙ               ｃｏｍｐｏｎｅｎｔ               ｉｎ               ＤＮＡ               ａｓｓｅｍｂｌｉｎｇ               ａｎｄ               ｐａｃｋｉｎｇ.                Ｄｒ. Ｇｕｐｔａ               ａ               ｒｅｓｅａｒｃｈｅｒｓ               ｂｅｌｉｅｖｅ               ｔｈａｔ               ｉｆ               ｔｕｍｏｒｏｕｓ               ｃｅｌｌｓ               ｃｏｕｌｄ               ｂｙ               ｓｏｍｅｈｏｗ               ｄｅｐｌｅｔｅｄ               ｏｆ               ＭＯＦ               ｔｈｅｙ               ｃｏｕｌｄ               ｋｉｌｌ               ｔｈｅ               ｃａｎｃｅｒｏｕｓ               ｃｅｌｌｓ               ａｎｄ               ｈｅｎｃｅ               ｔｈｅ               ｔｕｍｏｒ. Ｂａｓｉｃａｌｌｙ               ｂｙ               ｔａｒｇｅｔｉｎｇ               ＭＯＦ               ｉｎ               Ｃａｎｃｅｒ               ｃｅｌｌｓ               (ｂｕｔ               ｎｏｔ               ｉｎ               ｈｅａｌｔｈｙ               ｃｅｌｌｓ)               ｔｈｅ               ｔｕｍｏｒ               ｗｉｌｌ               ｄｉｅ.                Ｔｈｅｙ               ａｌｓｏ               ｆｏｕｎｄ               ｔｈａｔ               ｃｅｌｌｓ               ｗｉｔｈ               ｌｅｓｓ               ＭＯＦ               ｗｅｒｅ               ｍｏｒｅ               ｓｅｎｓｉｔｉｖｅ               ｔｏ               ｒａｄｉａｔｉｏｎ               ｅｘｐｏｓｕｒｅ. Ｓｏ               ａ               ｋｅｙ               ｉｎ               ｍａｋｉｎｇ               ｒａｄｉａｔｉｏｎ               ｔｈｅｒａｐｙ               ｍｏｒｅ               ｅｆｆｅｃｔｉｖｅ               ｉｓ               ｆｉｎｄｉｎｇ               ｗａｙｓ               ｔｏ               ｄｅｐｌｅｔｅ               ｃａｎｃｅｒｏｕｓ               ｃｅｌｌｓ               ｏｆ               ＭＯＦ. Ｒｅｓｅａｒｃｈｅｒｓ               ａｒｅ               ｗｏｒｋｉｎｇ               ｈａｒｄ               ｔｏ               ｉｄｅｎｔｉｆｙ               ｉｎｈｉｂｉｔｏｒｓ               ｏｆ               ＭＯＦ.                Ｏｎ               ｔｈｅ               ｃｏｎｔｒａｒｙ,               ｗｈｅｎ               ｔｈｅ               ｒｅｓｅａｒｃｈｅｒｓ               ｉｎｃｒｅａｓｅｄ               ＭＯＦ               ｉｎ               ｃｅｌｌｓ,               ｔｈｅ               ｃｅｌｌｓ               ｒｅｐｌｉｃａｔｅｄ               ａｎｄ               ｄｉｖｉｄｅｄ               ｆａｓｔｅｒ               ａｎｄ               ｓｈｏｗｅｄ               ｓｉｇｎｓ               ｏｆ               ｃａｎｃｅｒｏｕｓ               ｔｒａｎｓｆｏｒｍａｔｉｏｎ. Ｗｈｅｎ               ｔｈｅｓｅ               ＭＯＦ-ｒｉｃｈ               ｃｅｌｌｓ               ｗｅｒｅ               ｉｎｊｅｃｔｅｄ               ｉｎｔｏ               ｍｉｃｅ,               ｔｕｍｏｒｓ               ｇｒｅｗ               ｆａｓｔｅｒ.                ＭＯＦ               ｉｓ               ｗｈａｔ               ｃｏｕｌｄ               ｂｅ               ｎｅｅｄｅｄ               ｔｏ               ｋｎｏｃｋ               ｏｆｆ               ｃａｎｃｅｒ               ｃｅｌｌ               ｄｅｖｅｌｏｐｍｅｎｔ               ａｎｄ               ｐｒｏｌｉｆｅｒａｔｉｏｎ. Ｂｙ               ｂｌｏｃｋｉｎｇ               ｔｈｉｓ               ｍｏｌｅｃｕｌｅ               ｒａｄｉａｔｉｏｎ               ｃｏｕｌｄ               ｂｅ               ｅｘｈｏｒｔ               ｉｔｓ               ｂｅｎｅｆｉｃｉａｌ               ｅｆｆｅｃｔ               ｍｏｒｅ               ａｃｃｕｒａｔｅｌｙ               ａｎｄ               ｆａｓｔｅｒ.                Ｓｏｕｒｃｅ:                Ｇｕｐｔａ,               ａｎｄ               ｃｏｌｌｅａｇｕｅｓ. 2007. Ｍａｍｍａｌｉａｎ               ｏｒｔｈｏｌｏｇ               ｏｆ               Ｄｒｏｓｏｐｈｉｌａ               ＭＯＦ               ｔｈａｔ               ａｃｅｔｙｌａｔｅｓ               ｈｉｓｔｏｎｅ               Ｈ4               ｌｙｓｉｎｅ               16               ｉｓ               ｅｓｓｅｎｔｉａｌ               ｆｏｒ               ｅｍｂｒｙｏｇｅｎｅｓｉｓ               ａｎｄ               ｏｎｃｏｇｅｎｅｓｉｓ. Ｍｏｌｅｃｕｌａｒ               ａｎｄ               Ｃｅｌｌｕｌａｒ               Ｂｉｏｌｏｇｙ               (ａｄｖａｎｃｅ               ｏｎｌｉｎｅ               ｐｕｂｌｉｃａｔｉｏｎ).

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